I know you can change the uuid if you choose, but if left alone does it remain the same. Specifically I'm upgrading my motherboard but am unsure if I'll need to alter my fstab with new uuids or if all that information will remain the same.
SnapOverflow
No, it should not change. The reasoning for this is because the UUID is stored in the filesystem metadata.
However, when you change your motherboard, there may be other settings you need to change. Often a reinstall is required, which will change your UUID.
The only other reason why the UUID would change is if the driver software for the motherboard changes the UUID, but if it does that, you should be questioning why it changes the UUID.