Wine and system audio mute one another

I'm running into an awkward problem. Here's the thing:

If I start up my computer and run a Wine instance (Guild Wars 2, in this case, though it doesn't and shouldn't matter), sound works fine. While the sound works, the application does not show up under the "sound" tab in settings. And any other application launched thereafter will not have sound until the Wine instance is closed. I'm assuming Wine runs ALSA.

If I start any other application that requires sound before running Guild Wars 2, Guild Wars 2 will not have any sound. All the other applications appear to run pulseaudio.

Does this sound familiar to anyone?