Single Nginx Docker vs Multiple Nginx Docker for websites

Forgive me if I am asking a stupid question, but I am building a server where I will host multiple Flask websites Docker Container using Nginx Docker. My question now is: is it better to have one main nginx docker container and then host all my Websites Docker containers on it or have an Nginx docker container for each application with docker compose?

I want to know in terms of resource handling and efficiency which one is better to go for ?

@Jacob Following your answer, i am trying to setup something like this

docker-compose.yml:

version: "3.8"

services:
  portfolix:
    container_name: portfolix
    image: mervin16/portfolix:dev
    env_file:
      - config_local.env
    expose:
      - 8086
    restart: always
    networks:
      - sky_net

  mes:
    container_name: mes
    image: mervin16/mes:dev
    networks:
      - sky_net
    expose:
      - 8085
    restart: always

  nginx:
    build: ./nginx
    container_name: nginx
    ports:
      - "8085:85"
      - "8086:86"
    restart: always
    networks:
      - sky_net

networks:
  sky_net:
    name: sky_network
    driver: bridge

Now each website is available on localhost:8085 and localhost:8086

I am then using a reverse proxy on Nginx (not docker but the one installed on my server) to redirect traffic to my domain name:

server {

server_name   mes.th3pl4gu3.com;

  location / {
    access_log  /var/log/nginx/mes/access_mes.log;
    error_log  /var/log/nginx/mes/error_mes.log;
    proxy_pass  http://localhost:8081;
  }

    listen 443 ssl; # managed by Certbot
    ssl_certificate /etc/letsencrypt/live/mes.th3pl4gu3.com/fullchain.pem; # managed by Certbot
    ssl_certificate_key /etc/letsencrypt/live/mes.th3pl4gu3.com/privkey.pem; # managed by Certbot
    include /etc/letsencrypt/options-ssl-nginx.conf; # managed by Certbot
    ssl_dhparam /etc/letsencrypt/ssl-dhparams.pem; # managed by Certbot

}
server {
    if ($host = mes.th3pl4gu3.com) {
        return 301 https://$host$request_uri;
    } # managed by Certbot


 listen        80;
  server_name   mes.th3pl4gu3.com;
    return 404; # managed by Certbot


}