My motherboard has a slot on the motherboard for,
JPI2C1 Power Supply SMBus I2C Header (X13SAE-F only)
What is this used for? The motherboard manual say nothing more about it. What is this for? What do I plug in there? What happens if I plug nothing in there?
The system management I²C bus is used for various purposes, most commonly:
There may be vendor options that connect to the I²C header - either additional monitor/actor chips (case temperature sensors, smart PSU monitoring), or optional monitoring or management like IPMI / lights-out management. There may also be third-party options that you can plug in and use. There's no need to plug in anything though.
Workstation and server boards may use multiple I²C busses.