We've implemented AppLocker with a baseline set of default rules that allow items to be run from program files, windows and some outside folders (like a custom folder for users to put portable apps). This removes the ability for clickonce junk to install as they most of the time launch from the profile.
Not only does this assist keeping clickonce off our computers and out of user's profiles...but it basically stops drive by malware in its tracks.
Use Applocker.
We've implemented AppLocker with a baseline set of default rules that allow items to be run from program files, windows and some outside folders (like a custom folder for users to put portable apps). This removes the ability for clickonce junk to install as they most of the time launch from the profile.
Not only does this assist keeping clickonce off our computers and out of user's profiles...but it basically stops drive by malware in its tracks.