I have a router and I have the chance to receive the WAN connection either from a Serial port (Smart Serial) or T1/E1. I have both cards for Serial and E1/T1 interfaces. I really don't know what are the pros/cons from one to another.
Can anyone help me?
If you mean a serial port vs a T1 port on your router, I would recommend the T1 port. An "old-style" V.35 serial port requires an external CSU/DSU, which these days is just another piece of equipment to power, troubleshoot, etc. Do you have the exact model numbers of your interfaces?
Serial will play nicer with a variety of devices, like Video Codecs (Tandberg, Polycom), Line Encryptors (KIV-7, KIV-7M, KIV-19M), and most setups that require RS-366 lines. T1/E1 will only play with T1/E1 lines...
Also serial is superior now that it can push 50Mbps or more on modern devices (Including Cisco)