Doing my first server to iSCSI target and I thought i would be off to a running start by teaming my NIC on the server (conventional 802.3ad team).
However, from many online sources I see this is NOT recommended and MPIO should be used instead (there was no specific sizing in this recommendation and seemed to apply from a 3 node cluster to large clusters of tens of nodes and above).
I know MPIO is better as it aggregates transfers over independent routes (whereas conventional NIC team would be to the same switch), this aside is there any other reason (risk of data corruption) for Microsoft and training material state to use MPIO instead of teaming?
Can you expand a bit on your iSCSI architecture? How many initiator/target addresses are you working with, how many physical switches, all one subnet or multiple?
The basic answer is: because MPIO manages end-to-end connectivity paths, and is better at storage connectivity load balancing and connection resilience than generic network redundancy and load balancing mechanisms.
The specific technical reasons for this depend on the architecture, so I can be a lot more specific if you provide additional detail on your iSCSI network's setup. A few general examples: