I have installed the Data Deduplication role on Windows Server 2016. Per Microsoft, it's using NTFS compression to help save space:
Data deduplication stores more data in less physical space. It achieves greater storage efficiency than was possible by using features such as Single Instance Storage (SIS) or NTFS compression. https://technet.microsoft.com/en-us/library/hh831602(v=ws.11).aspx
Should I also enable NTFS compression in the volume's properties (see screenshot below)? Would there be any benefit?
What if it was already checked? Should I uncheck it? Would there be any negative effects of having it checked?